Recorded answers
12,456 recorded answers
How to approach it
Approach the prompt as a chemistry problem hiding inside ordinary language. Begin with the outputs you could name in a sentence, then deliberately drop one level: which tissue builds it, from which precursor, under which enzyme, and what does the finished molecule get called in a metabolic index? The reveal here was plainly generated from a large compound catalogue, so breadth of coverage matters more than tidy phrasing. After a few safe everyday entries, push into pathways — lipid handling, steroid conversion, amino acid breakdown, sugar interconversion, inflammatory signalling — and give the systematic chemical name instead of the nickname. Keep every guess to a single substance, spell it the way a database would, and drop anything the body merely absorbs, receives as a medicine, or hosts from outside.
Get a hint
Body systems make a better map than single organs: digestion, circulation, hormone signalling, immune defence and waste clearance each leave distinct chemical traces that qualify as substances the body has produced.
A little more
Then move to process: whatever is built during synthesis, released during signalling, burned for energy or broken down for excretion is fair game, including short-lived intermediates that never reach an easily named fluid.
One step further
Aim for named chemical families rather than everyday words — acids, salts, alcohols, esters, sugar conjugates, glycoproteins and their carrier-bound forms — and include the long systematic names that only a metabolic database would list.
Reveal answers 12,456
- E3 ubiquitin-protein ligase HECW2Deep Cut85points
- E3 ubiquitin-protein ligase HERC1Deep Cut85points
- E3 ubiquitin-protein ligase HERC2Deep Cut85points
- E3 ubiquitin-protein ligase HERC3Deep Cut85points
- E3 ubiquitin-protein ligase HUWE1Deep Cut85points
- E3 ubiquitin-protein ligase IRF2BPLDeep Cut85points
- E3 ubiquitin-protein ligase Itchy homologDeep Cut85points
- E3 ubiquitin-protein ligase KCMF1Deep Cut85points
- E3 ubiquitin-protein ligase listerinDeep Cut85points
- E3 ubiquitin-protein ligase LNXDeep Cut85points
- E3 ubiquitin-protein ligase LRSAM1Deep Cut85points
- E3 ubiquitin-protein ligase makorin-3Deep Cut85points
- E3 ubiquitin-protein ligase MARCHF2Deep Cut85points
- E3 ubiquitin-protein ligase MARCHF5Deep Cut85points
- E3 ubiquitin-protein ligase MARCHF6Deep Cut85points
- E3 ubiquitin-protein ligase MARCHF7Deep Cut85points
- E3 ubiquitin-protein ligase MIB1Deep Cut85points
- E3 ubiquitin-protein ligase MIB2Deep Cut85points
- E3 ubiquitin-protein ligase MID1Deep Cut85points
- E3 ubiquitin-protein ligase MID2Deep Cut85points
- E3 ubiquitin-protein ligase MYCBP2Deep Cut85points
- E3 ubiquitin-protein ligase MYLIPDeep Cut85points
- E3 ubiquitin-protein ligase NEDD4Deep Cut85points
- E3 ubiquitin-protein ligase NEDD4-likeDeep Cut85points
- E3 ubiquitin-protein ligase NEURL1Deep Cut85points
- E3 ubiquitin-protein ligase NEURL1BDeep Cut85points
- E3 ubiquitin-protein ligase NHLRC1Deep Cut85points
- E3 ubiquitin-protein ligase NRDP1Deep Cut85points
- E3 ubiquitin-protein ligase PDZRN3Deep Cut85points
- E3 ubiquitin-protein ligase pellino homolog 1Deep Cut85points
- E3 ubiquitin-protein ligase pellino homolog 2Deep Cut85points
- E3 ubiquitin-protein ligase PPP1R11Deep Cut85points
- E3 ubiquitin-protein ligase Praja-1Deep Cut85points
- E3 ubiquitin-protein ligase Praja-2Deep Cut85points
- E3 ubiquitin-protein ligase RAD18Deep Cut85points
- E3 ubiquitin-protein ligase RBBP6Deep Cut85points
- E3 ubiquitin-protein ligase RBX1Deep Cut85points
- E3 ubiquitin-protein ligase rififylinDeep Cut85points
- E3 ubiquitin-protein ligase RING1Deep Cut85points
- E3 ubiquitin-protein ligase RING2Deep Cut85points
- E3 ubiquitin-protein ligase RLIMDeep Cut85points
- E3 ubiquitin-protein ligase RNF10Deep Cut85points
- E3 ubiquitin-protein ligase RNF113ADeep Cut85points
- E3 ubiquitin-protein ligase RNF114Deep Cut85points
- E3 ubiquitin-protein ligase RNF115Deep Cut85points
- E3 ubiquitin-protein ligase RNF123Deep Cut85points
- E3 ubiquitin-protein ligase RNF125Deep Cut85points
- E3 ubiquitin-protein ligase RNF128Deep Cut85points
- E3 ubiquitin-protein ligase RNF13Deep Cut85points
- E3 ubiquitin-protein ligase RNF135Deep Cut85points
Why these answers count
Scoring tracked obscurity rather than plausibility across 12223 recorded answers. Everyday entries — a hormone, a digestive fluid, a structural protein — drew so many identical submissions that they sank into the crowded tail, while names lifted from a comprehensive metabolic index rose to the top. The single 100-point answer, Lubricin, is a joint-lining glycoprotein most players would never reach, which is precisely why it was scarce and expensive. The 85-point band, with 11967 entries, is where the long systematic names live: (10Z,13Z,16Z)-docosatrienoic acid, (11R)-HPETE, (13Z)-octadecenoyl-CoA and dozens more fatty acid, carnitine and coenzyme A conjugates. These are genuine products of human enzymes, yet nobody writes them from memory, so few guesses matched. Only 201 answers scored 60, the consolation band for mid-rare picks. The lesson: the reveal drew on a catalogue of tens of thousands of compounds, and points rose with how unlikely a name was to be guessed rather than with how central it is to human biology.